Control of oligodendroglial cell number by the miR-17-92 cluster

Control of oligodendroglial cell number by the miR-17-92 cluster.

The generation of myelinating cells in the central nervous system requires the initiation of specific gene expression programs in oligodendrocytes. We reasoned that microRNAs (miRNAs) could play an important role in this process by regulating crucial developmental genes. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocyt...

control of the optical properties of nanoparticles by laser fields

در این پایان نامه، درهمتنیدگی بین یک سیستم نقطه کوانتومی دوگانه(مولکول نقطه کوانتومی) و میدان مورد مطالعه قرار گرفته است. از آنتروپی ون نیومن به عنوان ابزاری برای بررسی درهمتنیدگی بین اتم و میدان استفاده شده و تاثیر پارامترهای مختلف، نظیر تونل زنی(که توسط تغییر ولتاژ ایجاد می شود)، شدت میدان و نسبت دو گسیل خودبخودی بر رفتار درجه درهمتنیدگی سیستم بررسی شده اشت.با تغییر هر یک از این پارامترها، در...

miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity

Downlo ammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, ing apoptosis and senescence, which are compromised by additional mutations before cancers are develThe miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed an cancers and has been shown to promote several aspects of oncogenic transformation, ...

The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis

MicroRNAs (miRNAs) are now recognized as essential regulators of gene expression in plants and animals. They potentially modulate the expression of multiple genes thereby enabling homeostatic settings in physiological conditions. Their role is also increasingly considered in many diseases in which deregulated epigenetic mechanisms induce aberrant gene expression. Work conducted in our laborator...

New Insights Into miR-17-92 Cluster Regulation and Angiogenesis.